I found something that worked for me, so I made an account.
The problem I was experiencing on my Samsung Mesmerize was that the preferences would open, then immediately close. the standard troubleshooing solutions did nothing to help this (reinstalling/uninstalling an alternate launcher program/taking the battery out).
So, as soon as I tapped "preferences" I started tapping in the middle of the screen and hit, for example, "app drawer settings."
Then, "app drawer settings" opened up, but immediately closed to to the preferences screen, but the preferences stayed open.
This did not fix the problem, as every time I had to open preferences, I had to keep tapping to, again, open up another selection which would close back to the preferences screen.
But, if you can get to the preferences screen, go to "advanced settings" and make sure "system persistent" is checked. After this, my preferences screen opens up without a problem.
Hope this helps, because I never did find this solution anywhere else.