I haven't tried with jellybean, but I did try to use Boot Animation Changer with ICS on my Reverb and it ended up looping the new animation, then I had to reflash my phone to stock. After that I stopped trying to change the boot animation.
So basically my advice is - yes, it's possible, but be cautious how you do it. And don't use BAC!
Edit: I should retract my ill speak of BAC, it appears it was the phone, not the app. It should work with the method linked below