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you can use titanium backup to backup everything then save a copy of the folder to your computer.
This is handy but requires much more hacking up of your phone. To do a Nandroid backup you need to first use ROM Manager to install the ClockworkMod Recovery image to your phone, which replaces your stock boot manager. I've not heard how one can easily undo that if they choose to later and want to return to the stock boot manager.you can also use a nandroid image through rom manager and clockwork recovery to save a "snapshot" of your phone at the time you back it up.
Do all of these methods require rooting? If not, which ones don't?