Yep, to what Scotty says, my DHD couldn't take anything more than a - 25mV across the board. Any more and it wouldn't boot.
You're best to start off small, test for a bit and once you're happy it's stable, lower again.
There's an app called System Tuner which will do it for you if you're not comfortable with the inbuilt Daemon. It doesn't change the specific system file for UV so if there are issues (it applies the values on a successful boot) and your device reboots constantly, it will restore the default values apparently.
No idea how it works, but I've used it no problem on my One X.