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Did you order it online or pick it up retail? If retail, I'd walk it back to the store and swap it ... online you have to deal with rma's and shipping and crap. Only you can tell how much it will drive you crazy.
I got mine last week and it came with a bright pixel. On the first day i cringed and decided to give it a day before returning it, because technically a single bright pixel is within the acceptable fault specifications for displays. Fortunately after using it for a day, the bright pixel when away. I realize a smudge won't ever go away, but if you only see it when you hold the pad a certain way or when it's off ... i guess i'd have to see it to decide.
Not much help, was I?

you're talking about the white blotch next to the folder icon?
Thanks guys. I'll be sending it back for sure, also noticed what looks like some debris stuck behind the glass in the left corner.
But do I go through Asus or the Retailer, Asus should be faster?