The biggest problem mizzou is going to have is fighting for recruits. Especially when you're trying to convince a high ranking prospect to choose mizzou when schools like LSU, Bama, Flordia, UGA, AU, and South Carolina are going after the same prospects. Also with mizzou coming from the BIGXII they are not going to be prepared for SEC defenses. They also dont have the depth on the O and D-line to go through an SEC season.
As most people that follow college football know the big12 was an offensive heavy conference. No team in the big12 has a defense that can prepare them for the kind of defenses they are going to see in the SEC. Also every game in the SEC is a battle. There are no "off" weeks. Even teams like Ole Miss and Kentucky are no pushovers. No more Iowa States, Kansas, and Texas Tech's. I think it's going to be a rough season for mizzou AND TA&M.