I've removed gmail and talk as I don't use those. I only have gmail acccount so that I could sign in to google play store, that's it. I mainly use my yahoo account. So far i haven't noticed any ill effects from removing those from system/app.
I noticed that in system/app there's this talkback.apk. Is that related to talk.apk? and if that's okay to be removed too?
Im running cyanogenmod 10.1 4.2.2 from dastin. Loving it and I want to remove anything that I don't use and keep the system as minimalistic as possible.
EDIT: So far I've removed Gmail, Talk, Browser, Sound Search for Google Play, and Terminal Emulator from system/app.
Rom is running fine without those, which I don't use/need.