If by "screen is locked" you mean the security pattern has been forgotten (and you're seeing the "too many attempts" prompt), you'll have to "start over" with the device by creating a new Gmail account from your computer, then taking the steps to associate that account with the locked device.
If by "locked" you mean that the device won't power up or hangs at some point during booting up, then we have a technical issue to deal with and need more info.
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