I've rooted every phone I've ever had, since the original iPhone.
No root here might be tough 6 months down the line, but for now, I'm not missing it too much.
There's a few obvious things I'm missing already, like bypassing the tethering restrictions, but with the ability to "freeze" the little bit of bloatware on the phone, and a relatively nice/clean vanilla android running on it (no need for ROMming), it hasn't been a deal-killer this first week of ownership.
One thing I *really* miss root on already, though, is Tasker! I was trying to setup some Tasker profiles that unlock the phone when I'm within range of my home WiFi, and re-lock it when I am out of range. They work, as long as I use a PIN instead of a pattern lock. Apparently pattern locks need root access to have this kind of Tasker control. :-(
That aside, for the general public who doesn't even know what root is, this is a fantastic phone. Good display, not HTC One great, but good, AMAZING battery life, and some really good features that we won't see on competitors for a while. Well done, Googlerola.