The Virtuous ROM is very close to stock HTC Sense for the Incredible, so by flashing it, you are closest to stock, but by doing so, you also now have the ability to make slight changes to the interface, such as:
1. The icons in the notification bar (e.g. "Conservative" color icons)
2. How you interact with the notification bar (e.g. "Powerwidgets" pull-down menu)
3. What kind of unlock screen you use (e.g. Rotary Lockscreen)
Plus, you can switch your kernels from the Virtuous-supplied kernel to other kernels that either enhance battery life, or allow you to overclock, or both, or some other combination (for instance, I use HeyIt'sLou's #4 kernel with Virtuous 3.2).
In other words, it's a good place to start, with the ability to make incremental changes.
With Skyraider Sense or Myn's Warm Two Point Two you make more drastic changes (although I believe both are also very stable ROM's).