out of the box the phone is set up fairly well for a newb, just get used to browsing the web, using voice commands, email, texting etc...
after that, there are a few apps I highly recommend:
swiftkey 3 (costs a few bucks, but WORTH EVERY PENNY, it's a keyboard replacement app that works much better than the out of the box one and will save you a ton of time typing on the touchscreen)
titanium backup (free version or pro version to backup your data/apps in case you have to reset your phone)
boat browser (free browser app replacement)
go launcher (free launcher replacement)
If you are feeling adventurous I would highly recommend rooting your phone and going to a custom ROM, my own personal favorite is the n00b ROM that I put together, but there are many good ROMS available for this phone and tons of people willing to help you root/install a ROM (look up n0ve sometime, he is very capable and loves to help people root/configure their phones).