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They are tied to the four shortcuts in your dock.
Not sure I understand what you mean... In your dock?
Sorry, the four shortcuts at the bottom of each screen. HTC refers to them as launch shortcuts. The lock screen shortcuts, if enabled in the personalize settings, will be the same as the four shortcuts at the bottom of the screen.
OK, gotcha... but back to my original question then... Are the ones on the home screen changeable then?