Yes and no. I'm greatly enjoying my Desire and am impressed by the variety of solutions/apps available. However, as a security-conscious person I am concerned that at this early stage of Android's career there is no easy/reliable way to find out if a given app is clean. In the Market the apps have notes in red saying that, for example "This app accesses the Internet", or "This app accesses your Contacts" where I cannot see any reason why the app should do any of these things. It is, in most cases, difficult to find out WHY the app wants to do these things.
The bottom line for me is that I don't store any data (e.g. in Contacts) which I don't want others to see or steal. But then I'm careful by nature. Others are less so.