I picked up a case not because of calling issues but because I didn't want to drop my phone and break it, Otterbox makes great cases. Again, I think you are jumping into conclusions based on Fanboys going crazy instead of having used the phone for an extended period of time. Have you ever owned one?
The problem with your sister-in-law not being heard for two hours has nothing to do with the phone, never had such issues with mine. My wife owns one as well and is a happy customer, no complaints about reception. A lot of things make up a bad call, so to blame any phone without really understanding the root cause is insane.
One of the things I kind of like with the iPhone is iTunes believe it or not. I get to sync my music, apps and backup all my devices with it from one location. Again, like you, I'm looking for simplicity and not spending my day hacking a phone to get what I want.
Not sure which phone you are referring to when you say picking the wrong one but for me the Captivate was a mistake and I blame Samsung for that not Android. At least for now my GPS works, AppStore is great, have no lag and I'm getting frequent updates and/or new functionality (AirPrint/AirPlay) on a frequent basis. Let's see what's out there in two years when I take a look at Android again.