My understanding of the skin (full body) is that you would use it without a case to have the naked look while maintaining full surface protection. The problem as I see it is it doesn't offer any impact protection (like if you dropped it).
I hear good things about the TPU cases, but I will always go for a quality hard case like Seidio or Otterbox (I prefer the Seidio because it is so low profile, but many really like the otterbox).
The orange peel effect is like the surface of an orange. Almost dimpled, almost textured. If you tilt your device in the light you will notice the orange peel effect, but likely wont otherwise.
I think a TPU case and screen protector sounds like a good combo if you really want a seemless look, but if the seemless aspect isn't as important to you, I still recommend a hard case.
On a side note: some say the DInc2 has Gorilla Glass and that there is no need for a screen protector, but I always use them since a good one doesn't effect the performance or use and gives MORE protection (no screen is perfect or impervious)