I gues you are looking for Windows like user accounts. I don't know of any device based on Android that has this facility. The only thing you can individualise are mail accounts and even then the tab will automatically sync all mail accounts without user intervention, unless you select not to sync a particular one in the system settings. As far as individual per-user "desktop" settings are concerned - no, you can't.
I suspect tablet OSs were conceived to be linked to a user and not layed out for multi-user GUI variances.