It all depends on the OTA.
They can modify just rom bits harmlessly, or pack in any number of things that will cause sadness.
In this case, the OTA is known to require the stock recovery and by all accounts, you'll have to apply an RUU (HTC stock, complete image for the phone, wipes 100% of everything), take the OTA, and then go from there.
I have the exact same sensitivity to the camera and gallery.
And you have another option, although it still requires an RUU.
You can advance to Sense 5.5 and Android 4.3 (immune to Heartbleed).
In addition to that, it will change your partition layout - think of it as having your internal SD card and /data (where your apps and data go) shared as one volume.
Your present nandroids will NOT work with that.
If you want to go that route, I recommend going all the way to Viper4G -
http://forum.xda-developers.com/showthread.php?t=2693615
The Heartbleed OTA was pulled into a zip file on May 8th. So far, I haven't seen any devs working to put it into a 4.1.1 rom.
So - what you need -
Choice 1 - apply 4.1.1 RUU, accept OTA, redo all unlocking, install TWRP and root steps (don't use your old nandroids or you'll step on the fix).
Choice 2 - apply 4.3 RUU, redo unlocking, install TWRP, and flash Viper4G (and don't use your old nandroids).
Clear?