While these phones are very similar technically (aside from 4G) I found the size difference to be significant.
The Inc2 is a much slimmer and lighter device in the hand (and by the measurements too); the TB felt like a brick by comparison. I keep my phone in my front pocket 90% of the time, and the smaller inc2 is better there too.
Even though I'm in an emerging 4G area, I actually chose the Incredible 2 over the TB because of the size/battery issues. Maybe I'll regret that in a year from now, but when it came down to it, I wanted the phone that was pleasant to use and carry over the phone with faster data speeds. My other choice would've been an iPhone4 (I'm upgrading an old 3G), which also lacks 4G, and I ultimately think the Dinc2 is a superior device (we'll see how I handle Android vs. iOS).