It does run differently on Home rather than Sense. The apps load instantaneously, and it's easy to see that the whole system is using less resources in that mode.
I went back and forth a couple of times to test it further, just to my eye if you know what I mean.
I think a lot of people who use the Eris, many who have posted here, will want to use it in Home because they have a lot of apps, a lot of daily usage as "power users," etc. They will be pleasantly surprised that Sense is a bit of a hog with the device's cpu and that Home solves that.
I went ahead and put Sense back in as my default (a simple choice as the Eris boots up; there's a check mark for "use as default" in the Home and Sense choice offered then) because, in my case, the quickness of the apps loading, etc, is pretty good with Sense being as how I only have the default apps in there and two others: Spare Parts and Brickbreaker.
Basically speaking, I don't need to disable Sense, but a lot of Eris users should if they want an increase in speed of the display, etc. It's fast enough for me with Sense invoked.
Thanks for showing that choice in here, yet another great tip found in the forums here.