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You may use more power in keep re-establishing the connection.
I'm convinced most peoples poor battery issues are linked with power hungry apps running in the back ground.
You're almost right danfrance, what disabling this actually does is turn off mobile data when you lock the phone then re-enable it when you unlock the phone so if you check your phone regularly you will use a lot of juice re establishing the connection
I use this option and everything seems to sync fine. The mobile data connection sleeps until used but it wakes when needed. The statement above may bemore of a disclaimer