hey spacedementia,
I used the modaco r6 root method (with bootloader 0.80) last night. the guide is simple, it looks too simple and that is always worrying, but the fact it that there's nothing to it, and if you follow it you should have no problems.
my tips:
1. dont panic!! a number of the stages take time and look like nothing doing, and your fone will turn off and on and appear to have crashed, and show an htc screen you havent seen before, and... dont panic!!
2. make sure HTCSYNC is installed on pc (it doesnt have to be open/running, in the system tray is enough)
3. make sure you 'copy' the update.zip from the unzipped r6 to sdcard, but leave the original copy (zipped, as is) in the pc directory... I 'cut' it and then had to go through most of an evening of PANIC!! until I worked out my mistake.
4. if you do get errors on the fone, dont panic... just reboot it from the list... if it hangs on reboot, dont panic... remove the battery if nothing doing. Then, without panicking, make sure you have completed each step as instructed. and everything is where it should be. Then repeat
5. DONT panic... take your time, and you can get it right first time... if you do, you will have a rooted desire in well under an hour
6. follow lekky's (great) instructions to install DeFrost & radio (after Titanium Backup, rom manager etc) or whatever rom you like
7. stay cool, dont panic; done it once and it's easy, and the rom manager approach is the biggest doddle ever
Please don't take offence, I am not being condescending; this is a set of tips based on the mistakes I made and the fixes I thought through. Also, I am a pretty calm person, but was near freaking out at one stage when nothing was working. The irony is, I didn't like the new rom/android look & feel, so have unrooted and my desire is nearly back to how it was 24hours ago, I just have to tweak the last few settings. Rest assured that it is possible to return to the start!