I know that a lot of folks swear by this app, but I just disabled 'always on mobile data'. Doesn't affect email, talk, or messaging in any way, just certain things don't sync all the time automatically.
In the case of my phone's configuration, the only thing it affects is weather and news. I have the tiny Android news and weather widget on my main desktop; touching weather changes to the weather app screen and forces a refresh. Touching news changes to the news app screen and forces a refresh. So, they only sync when I want to view the information...I have no problem with that.
In fact, I've found that any app that no longer syncs automatically due to that system setting syncs automatically when I access the app, so I really see no downside. The upside is that this can save a great deal of battery time.
The downside is that if you're a person that wants the Facebook app to give you notifications every time someone posts, etc, that won't work. But, on my rooted ROM, I've removed the Facebook app completely (Titanium Backup), get Facebook notifications via email (not affected by the setting) and view them when I want via web browser. Again, no down side to me.
I'm not saying that this is the way to go, just 'a' way to go. I hope that it helps someone else. Thank you for your time.