I just figured out how I can get the best of both worlds. I love my Sense Home set up and widgets, but I did think it was more cluttered then I preferred it to be with all of the Widgets and apps that I wanted. I also don't like the fact Sense won't do landscape.
Messed around with LauncherPro Beta today and noticed you can launch it by bringing the shortcut to your home page in Sense. No need for the home switcher. When I'm in LauncherPro, I have it set up so when I press the home soft key, it will return instantly to the Sense home. It's like changing scenes in Sense on the fly, but it doesn't lag with loading scenes as I've experienced with Sense and using home switcher.
Now I'm moving all of my music apps and anything I will use when I'm in "Driving mode". I have changed the background to suit this "Scene" and I can use it in landscape mode when mounted in my car. I will leave everything else intact in my "Sense mode" with my calendars and contacts, email widgets, etc including it's different background.
Please note that the launcherpro icon was not in my list of apps to be able to bring the shortcut to my home screen until after I rebooted it. It showed up in launcherpro but not in Sense at first.
Maybe others will enjoy this set up as much as I do.