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So I haven't massively pushed it but the Desire, starting from a full charge at 7am easily lasted the entire day. This was with wi-fi off at work but some browsing and app installing over 3G during the day, then back on the wi-fi once I got home.
If you keep things to a minimum I don't think there'd be any problem with battery.
I am having no problems what so ever with my battery, so far I have twitter to auto fetch tweets, auto fetch email, syncing contacts between Google, 5 minutes phone calls, sent around 25 tweets, downloading apps from the android market, uploading various photos to flickr and basically just using the phone as much as I can and the battery has hardly changed in 9 hours of use.
This is by far the best battery I have had in any smartphone.