Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
Honestly, I've never used Titanium while hooked to the PC.
it doesn't "require" it, it just recommends it. I don't know why it does though.

Not to be snarky, but what does it matter?
I found that so many things I do with my phone require USB Debugging to be on that I just leave it on now. It's not really hurting anything to have it on so why keep turning it on and off?
You also say that "many things you do on the phone require USB debugging." This is the first that I have seen. What are some of the others?
Not snarky at all, it's a good question. I am guessing that keeping the USB port open to my PC when I have it connected in "USB Charge Only" mode might charge slower because it's actually maintaining an open connection to the PC drivers. The notification bar shows a status of connected to PC in Debug mode when it's on so I prefer it to be off. Other than that I just like to know why apps require the things that they do especially when they are Root permission apps. I am not sure what the app could do now that it has USB debug connection to my PC.