If you are pulling data over 4G all day that's going to be a big drain. 4G uses more battery than WiFi or even 3G. Its faster, but uses more power, so if you a transferring a file it is probably a wash, but if you are streaming anything 4G will drain much faster. Also, the constant data traffic in the background will use more power on 4G than 3G or WiFi.
If you can connect to wifi at work I would do so.
Also, I'm curious what "medium brightness" is. If you go into the display settings for brightness, is the slider at like 50%? I try to keep mine at 30% if I'm indoors to maximize battery life, and that is plenty bright for me. Its a huge screen so brightness and screen on time really have a big impact on battery life.