I cannot (well, barely). I don't make phone calls. I have four email accounts that I have set up to update every five minutes. I use Google Maps extensively (and the GPS is on, obviously) and some web use. I watched <1 minute of TV to see the quality (it's pretty darn good and I'm on 3G). Bluetooth is off; WiFi is off. I'll try having my email update less often... so far, I'm unimpressed with the battery life but I've not done more than a few charge/discharge cycles, yet, and often it takes 10+ to get the full capacity of out these types of batteries.
Well, update... I (foolishly) set up the FriendFinder (or whatever it's called) application that was just sitting there to sync up my twitter/facebook accounts. It sucks battery... removing that got me through almost a full 24 hour period without a charge (but it started at about 90% so it was not a full charge). So things are better... I do think the battery charges slowly; using the same charger as my Toshiba TG01, it takes a couple of hours to fully charge whereas my TG01 takes less than an hour. Smaller battery in the TG01 but not that much smaller. I'll try the HTC charger tonight to see if it's any faster.