The biggest difference between DxTop and any other home replacement I've seen/used is the four-homescreen setup. The screens are set up in a "plus symbol" shape, as in there is a top, bottom, left and right screen. To get to any of the other three from the one you're on, you'd swipe in the appropriate direction. For example, if you're on the left screen, swipe down to pull open the top screen, or up for the bottom... and left for the right. The cool thing about this is you can get to any screen with one swipe from the one you're on.
Secondly, there are two tabs at the bottom of the screen. The first is the traditional app listing, the second shows recently used and currently running applications. You can even long click (press, hold, wait for haptic feedback and release) to get to a contextual menu to end the process or get to more options. This works on the first tab as well.
Lastly, if you swipe the tabs left or right, it rotates out into a small dock that can hold any 1x1 icons or widgets for quick access to your top five items. If you've got this open and want to get to the tabs, you can swipe back or long press the menu or back buttons to open the appropriate tab immediately.
Also, I recently discovered the ability to apply labels/categories to all the apps in the app drawer, and then tell it to group them by category. Once I went through and applied the categories, I could easily show only games, or only system tools, etc. You can even create a shortcut on the desktop to open a folder showing all the apps in a category. You can even hide things you don't want to see in the drawer, like icon packs.
There's a ton more this thing does, I think it's completely worth the price of a small starbucks latte, haha. Check out:
DxTop home
androidforums.com - Why Dxtop is the best home replacment.