I will say that I have this issue. If I pause music. It will hiss for for a couple seconds, or in really low voume music, I will hear the interference. I also don't really like how it "improves" the bass. I use it in my car, and the bass comes out as muddled when I had no problem with my Dinc.
A couple other small issues i have. I really dislike how "flush" the power and volume buttons are, very hard to use at times. I dislike the small ridge that is around the screen (the rubber gasket on the screen), and the screen seems more smudgy than the SGSII that I used for a while.
None of these are huge issues, but I definitely won't be keeping it. Even if the GNex was delayed, I would return it and wait.